Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001040)
Formula Reactant Fingolimod Product Fingolimod carboxylic acid metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 4F2 (CYP4F2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001041 Fingolimod (S)-enantiomer of fingolimod-phosphate Other reaction - Phosphorylation Fingolimod [1], [2]
MR001043 Fingolimod . Unclear Fingolimod [3]
MR001042 Fingolimod Non-polar ceramides analogs of fingolimod Unclear Fingolimod [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001045 Fingolimod hydrochloride Fingolimod carboxylic acid metabolite Oxidation - Hydroxylation Fingolimod hydrochloride [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001039 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod [4]
MR001044 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod hydrochloride [4]
References
1 Clinical pharmacokinetics of fingolimod Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000.
2 Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition J Clin Pharmacol. 2009 Feb;49(2):212-8. doi: 10.1177/0091270008329553.
3 LABEL:INGOLIMOD capsule
4 CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.

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