Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001041)
Formula Reactant Fingolimod Product (S)-enantiomer of fingolimod-phosphate
Reactant Info Product Info
Metabolic Enzyme Sphingosine kinase 1 (SPHK1) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001043 Fingolimod . Unclear Fingolimod [1]
MR001040 Fingolimod Fingolimod carboxylic acid metabolite Oxidation - Hydroxylation Fingolimod [2]
MR001042 Fingolimod Non-polar ceramides analogs of fingolimod Unclear Fingolimod [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001046 Fingolimod hydrochloride (S)-enantiomer of fingolimod-phosphate Other reaction - Phosphorylation Fingolimod hydrochloride [2], [3]
References
1 LABEL:INGOLIMOD capsule
2 Clinical pharmacokinetics of fingolimod Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000.
3 Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition J Clin Pharmacol. 2009 Feb;49(2):212-8. doi: 10.1177/0091270008329553.

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