Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003768)
Formula Reactant MK-0859 Metabolite M1 Product MK-0859 Metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003763 MK-0859 MK-0859 Metabolite M1 Oxidation - O-demethylation MK-0859 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003772 MK-0859 Metabolite M1 MK-0859 Metabolite M10 Conjugation - Glucuronidation MK-0859 [2]
MR003771 MK-0859 Metabolite M1 MK-0859 Metabolite M13 Unclear MK-0859 [2]
MR003764 MK-0859 Metabolite M1 MK-0859 Metabolite M2 Oxidation - Hydrolyzationn MK-0859 [1]
MR003773 MK-0859 Metabolite M1 MK-0859 Metabolite M4 Unclear MK-0859 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003769 MK-0859 Metabolite M3 MK-0859 Metabolite M12 Oxidation - O-demethylation MK-0859 [2]
MR003770 MK-0859 Metabolite M3 MK-0859 Metabolite M8 Unclear MK-0859 [2]
References
1 Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. Drug Metab Dispos. 2010 Mar;38(3):474-83.
2 Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys

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