Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005072)
Formula
CBR1 ...
SVG example
Reactant Haloperidol decanoate Product Reduced haloperidol
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005080 Haloperidol decanoate 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+) Unclear Haloperidol decanoate [1]
MR005077 Haloperidol decanoate 4-(4-chlorophenyl)-4-hydroxypiperidine Oxidation - N-dealkylation Haloperidol decanoate [2]
MR005079 Haloperidol decanoate Fluorobenzoylpropionic acid Unclear Haloperidol decanoate [1]
MR005075 Haloperidol decanoate Haloperidol 1,2,3,6-tetrahydropyridine Other reaction - Dehydration Haloperidol decanoate [2]
MR005078 Haloperidol decanoate Haloperidol glucuronide Conjugation - Glucuronidation Haloperidol decanoate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005073 Reduced haloperidol Haloperidol reduced pyridinium ion derivative Unclear Haloperidol decanoate [2]
References
1 DrugBank(Pharmacology-Metabolism):Haloperidol decanoate
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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