Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005078)
Formula
SVG example
Glucuronidation
Reactant Haloperidol decanoate Product Haloperidol glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005080 Haloperidol decanoate 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+) Unclear Haloperidol decanoate [1]
MR005077 Haloperidol decanoate 4-(4-chlorophenyl)-4-hydroxypiperidine Oxidation - N-dealkylation Haloperidol decanoate [2]
MR005079 Haloperidol decanoate Fluorobenzoylpropionic acid Unclear Haloperidol decanoate [1]
MR005075 Haloperidol decanoate Haloperidol 1,2,3,6-tetrahydropyridine Other reaction - Dehydration Haloperidol decanoate [2]
MR005072 Haloperidol decanoate Reduced haloperidol Unclear Haloperidol decanoate [2]
References
1 DrugBank(Pharmacology-Metabolism):Haloperidol decanoate
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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