Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005079)
Formula
SVG example
Reactant Haloperidol decanoate Product Fluorobenzoylpropionic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005080 Haloperidol decanoate 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+) Unclear Haloperidol decanoate [1]
MR005077 Haloperidol decanoate 4-(4-chlorophenyl)-4-hydroxypiperidine Oxidation - N-dealkylation Haloperidol decanoate [2]
MR005075 Haloperidol decanoate Haloperidol 1,2,3,6-tetrahydropyridine Other reaction - Dehydration Haloperidol decanoate [2]
MR005078 Haloperidol decanoate Haloperidol glucuronide Conjugation - Glucuronidation Haloperidol decanoate [2]
MR005072 Haloperidol decanoate Reduced haloperidol Unclear Haloperidol decanoate [2]
References
1 DrugBank(Pharmacology-Metabolism):Haloperidol decanoate
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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