Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005080)
Formula
SVG example
Reactant Haloperidol decanoate Product 4-(4-Chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-pyridinium (HPP+)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005077 Haloperidol decanoate 4-(4-chlorophenyl)-4-hydroxypiperidine Oxidation - N-dealkylation Haloperidol decanoate [1]
MR005079 Haloperidol decanoate Fluorobenzoylpropionic acid Unclear Haloperidol decanoate [2]
MR005075 Haloperidol decanoate Haloperidol 1,2,3,6-tetrahydropyridine Other reaction - Dehydration Haloperidol decanoate [1]
MR005078 Haloperidol decanoate Haloperidol glucuronide Conjugation - Glucuronidation Haloperidol decanoate [1]
MR005072 Haloperidol decanoate Reduced haloperidol Unclear Haloperidol decanoate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005076 Haloperidol 1,2,3,6-tetrahydropyridine Haloperidol pyridinium ion derivative Unclear Haloperidol decanoate [1]
MR005074 Haloperidol reduced pyridinium ion derivative Haloperidol pyridinium ion derivative Unclear Haloperidol decanoate [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 DrugBank(Pharmacology-Metabolism):Haloperidol decanoate

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