Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005130)
Formula
SVG example
Reduction
Reactant Cortisone Product Tetrahydrocortisone
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005133 Cortisone 5-alpha Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005132 Cortisone 5-beta Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005131 Cortisone 6-beta-hydrocortisol Oxidation - 6-beta-hydroxylation Hydrocortisone [3]
MR005134 Cortisone 6alpha-hydroxy hydrocortisone Unclear Hydrocortisone [4]
MR010825 Cortisone Cortisol Unclear - Unclear Cortisone [5]
MR005129 Cortisone Dihydrocortisol Reduction - Reduction Hydrocortisone [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005758 Cortisone acetate Tetrahydrocortisone Unclear Cortisone acetate [7]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats
3 Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32.
4 Biotechnological transformation of hydrocortisone to 16-hydroxy hydrocortisone by Streptomyces roseochromogenes
5 Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial
6 DrugBank(Pharmacology-Metabolism):Hydrocortisone
7 Urinary steroid excretion after total adrenalectomy. III. Isolation and identification of the metabolites of cortisone acetate

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