Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005131)
Formula
SVG example
6-beta-hydroxylation
Reactant Cortisone Product 6-beta-hydrocortisol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Oxidation - 6-beta-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005133 Cortisone 5-alpha Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005132 Cortisone 5-beta Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005134 Cortisone 6alpha-hydroxy hydrocortisone Unclear Hydrocortisone [3]
MR010825 Cortisone Cortisol Unclear - Unclear Cortisone [4]
MR010828 Cortisone Tetrahydrocortisone(THE) Unclear - Unclear Cortisone [4]
MR005129 Cortisone Dihydrocortisol Reduction - Reduction Hydrocortisone [5]
MR005130 Cortisone Tetrahydrocortisone Reduction - Reduction Hydrocortisone [5]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats
3 Biotechnological transformation of hydrocortisone to 16-hydroxy hydrocortisone by Streptomyces roseochromogenes
4 Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial
5 DrugBank(Pharmacology-Metabolism):Hydrocortisone

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