Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010825)
Formula
SVG example
Unclear
Reactant Cortisone Product Cortisol
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005133 Cortisone 5-alpha Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005132 Cortisone 5-beta Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005131 Cortisone 6-beta-hydrocortisol Oxidation - 6-beta-hydroxylation Hydrocortisone [3]
MR005134 Cortisone 6alpha-hydroxy hydrocortisone Unclear Hydrocortisone [4]
MR010828 Cortisone Tetrahydrocortisone(THE) Unclear - Unclear Cortisone [5]
MR005129 Cortisone Dihydrocortisol Reduction - Reduction Hydrocortisone [6]
MR005130 Cortisone Tetrahydrocortisone Reduction - Reduction Hydrocortisone [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005759 Cortisone acetate Cortisol Unclear Cortisone acetate [7]
MR012916 NSC-63853 Cortisol Unclear NSC-63853 [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010827 Cortisol Allo\tetrahydrocortisol (allo\THF) Unclear - Unclear Cortisone [5]
MR010826 Cortisol Tetrahydrocortisol (THF) Unclear - Unclear Cortisone [5]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats
3 Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32.
4 Biotechnological transformation of hydrocortisone to 16-hydroxy hydrocortisone by Streptomyces roseochromogenes
5 Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial
6 DrugBank(Pharmacology-Metabolism):Hydrocortisone
7 Urinary steroid excretion after total adrenalectomy. III. Isolation and identification of the metabolites of cortisone acetate
8 The conversion in vitro of 17-hydroxypregnenolone to cortisol by a human adrenal tumor

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