Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005133)
Formula
SVG example
Reduction
Reactant Cortisone Product 5-alpha Tetrahydrocortisol
Reactant Info Product Info
Metabolic Enzyme Steroid 5-alpha-reductase 2 (SRD5A2) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005132 Cortisone 5-beta Tetrahydrocortisol Reduction - Reduction Hydrocortisone [1], [2]
MR005131 Cortisone 6-beta-hydrocortisol Oxidation - 6-beta-hydroxylation Hydrocortisone [3]
MR005134 Cortisone 6alpha-hydroxy hydrocortisone Unclear Hydrocortisone [4]
MR010825 Cortisone Cortisol Unclear - Unclear Cortisone [5]
MR010828 Cortisone Tetrahydrocortisone(THE) Unclear - Unclear Cortisone [5]
MR005129 Cortisone Dihydrocortisol Reduction - Reduction Hydrocortisone [6]
MR005130 Cortisone Tetrahydrocortisone Reduction - Reduction Hydrocortisone [6]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Subcellular distribution of 3H--hydrocortisone and its metabolites in the liver and kidneys of normal and alloxan diabetic rats
3 Cortisol metabolism in vitro--III. Inhibition of microsomal 6 beta-hydroxylase and cytosolic 4-ene-reductase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):827-32.
4 Biotechnological transformation of hydrocortisone to 16-hydroxy hydrocortisone by Streptomyces roseochromogenes
5 Long-term magnesium supplementation improves glucocorticoid metabolism: A post-hoc analysis of an intervention trial
6 DrugBank(Pharmacology-Metabolism):Hydrocortisone

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