Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005616)
Formula Reactant Selumetinib M14 (AZ12791138) Product Selumetinib M2 (amide glucuronide selumetinib metabolite)
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005614 Selumetinib Selumetinib M14 (AZ12791138) Unclear Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005615 Selumetinib M14 (AZ12791138) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
MR005624 Selumetinib M14 (AZ12791138) Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005617 Selumetinib M2 (amide glucuronide selumetinib metabolite) Selumetinib M1 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
MR005618 Selumetinib M2 (amide glucuronide selumetinib metabolite) Selumetinib M6 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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