Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005615)
Formula
SVG example
Elimination
Reactant Selumetinib M14 (AZ12791138) Product Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite)
Reactant Info Product Info
Metabolic Type Other reaction - Elimination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005614 Selumetinib Selumetinib M14 (AZ12791138) Unclear Selumetinib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005624 Selumetinib M14 (AZ12791138) Selumetinib M15 (AZ13326637) Hydrolysis - Amide hydrolysis Selumetinib [1]
MR005616 Selumetinib M14 (AZ12791138) Selumetinib M2 (amide glucuronide selumetinib metabolite) Conjugation - Glucuronidation Selumetinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005611 Selumetinib M8 (N-desmethyl selumetinib) Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Other reaction - Elimination Selumetinib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005612 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M10 selumetinib metabolite Oxidation - Oxidationn Selumetinib [1]
MR005619 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M13 (Primary amide, N-demethylated, mono-oxidized selumetinib metabolite) Oxidation - Oxidationn Selumetinib [1]
MR005620 Selumetinib M12 (Primary amide, N-demethylated selumetinib metabolite) Selumetinib M9 (ribose conjugated selumetinib metabolite) Conjugation - Ribose conjugation Selumetinib [1]
References
1 Metabolism, Excretion, and Pharmacokinetics of Selumetinib, an MEK1/2 inhibitor, in Healthy Adult Male Subjects

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