Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009128)
Formula Reactant AKB-6548 Product AKB-6548 Metabolite M6a
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009138 AKB-6548 AKB-6548 Metabolite M1 Hydrolysis - Hydrolysis AKB-6548 [1]
MR009139 AKB-6548 AKB-6548 Metabolite M2c Oxidation - Monooxygenation AKB-6548 [1]
MR009133 AKB-6548 AKB-6548 Metabolite M5 Oxidation - Methylation AKB-6548 [1]
MR009144 AKB-6548 AKB-6548 Metabolite M7 Conjugation - Glucosidation AKB-6548 [1]
MR009143 AKB-6548 Vadadustat acyl glucuronide Conjugation - O-glucuronidation AKB-6548 [2]
MR009142 AKB-6548 Vadadustat-O-glucuronide Conjugation - O-glucuronidation AKB-6548 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009129 AKB-6548 Metabolite M6a Vadadustat-1-O-beta-glucuronide Unclear - Unclear AKB-6548 [3]
References
1 Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control
2 DrugBank(Pharmacology-Metabolism):AKB-6548
3 U. S. FDA Label -AKB-6548

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