Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009143)
Formula Reactant AKB-6548 Product Vadadustat acyl glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009138 AKB-6548 AKB-6548 Metabolite M1 Hydrolysis - Hydrolysis AKB-6548 [1]
MR009139 AKB-6548 AKB-6548 Metabolite M2c Oxidation - Monooxygenation AKB-6548 [1]
MR009133 AKB-6548 AKB-6548 Metabolite M5 Oxidation - Methylation AKB-6548 [1]
MR009128 AKB-6548 AKB-6548 Metabolite M6a Conjugation - Glucuronidation AKB-6548 [2]
MR009144 AKB-6548 AKB-6548 Metabolite M7 Conjugation - Glucosidation AKB-6548 [1]
MR009142 AKB-6548 Vadadustat-O-glucuronide Conjugation - O-glucuronidation AKB-6548 [3]
References
1 Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control
2 U. S. FDA Label -AKB-6548
3 DrugBank(Pharmacology-Metabolism):AKB-6548

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