Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009139)
Formula Reactant AKB-6548 Product AKB-6548 Metabolite M2c
Reactant Info Product Info
Metabolic Type Oxidation - Monooxygenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009138 AKB-6548 AKB-6548 Metabolite M1 Hydrolysis - Hydrolysis AKB-6548 [1]
MR009133 AKB-6548 AKB-6548 Metabolite M5 Oxidation - Methylation AKB-6548 [1]
MR009128 AKB-6548 AKB-6548 Metabolite M6a Conjugation - Glucuronidation AKB-6548 [2]
MR009144 AKB-6548 AKB-6548 Metabolite M7 Conjugation - Glucosidation AKB-6548 [1]
MR009143 AKB-6548 Vadadustat acyl glucuronide Conjugation - O-glucuronidation AKB-6548 [3]
MR009142 AKB-6548 Vadadustat-O-glucuronide Conjugation - O-glucuronidation AKB-6548 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009140 AKB-6548 Metabolite M2c AKB-6548 Metabolite M11a Conjugation - Glucuronidation AKB-6548 [1]
MR009141 AKB-6548 Metabolite M2c AKB-6548 Metabolite M8a Conjugation - Sulfation AKB-6548 [1]
References
1 Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric Characterization of its Novel Metabolites in Equines for the Purpose of Doping Control
2 U. S. FDA Label -AKB-6548
3 DrugBank(Pharmacology-Metabolism):AKB-6548

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