Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012956)
Formula	Dehydrogenation; hydroxylation; reduction; oxidation
	Reactant	Ibrutinib	Product	PCI-45741 (M25)
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Multi-steps Reaction - Dehydrogenation; hydroxylation; reduction; oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012962	Ibrutinib	Desacryl-Ibrutinib	Unclear	Ibrutinib	[1]
MR012963	Ibrutinib	PCI-45227 (M37)	Multi-steps Reaction - Epoxidation; hydrolyzation	Ibrutinib	[2]
MR012958	Ibrutinib	PCI-45752 (M34)	Unclear	Ibrutinib	[2]
MR012954	Ibrutinib	PCI-45773 (M35)	Oxidation - Hydrolyzationn	Ibrutinib	[2]
MR012946	Ibrutinib	PCI-48303 (M26)	Conjugation - Glutathione conjugation	Ibrutinib	[2]
MR012961	Ibrutinib	PCI-7503 (M23)	Hydrolysis - Hydrolyzation	Ibrutinib	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012957	PCI-45741 (M25)	Ibrutinib Metabolite M20	Oxidation - Hydrolyzationn	Ibrutinib	[3]

References
1	Extrahepatic metabolism of ibrutinib
2	Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
3	DrugBank(Pharmacology-Metabolism):Ibrutinib

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