Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012961)
Formula
SVG example
Hydrolyzation
Reactant Ibrutinib Product PCI-7503 (M23)
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolyzation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012962 Ibrutinib Desacryl-Ibrutinib Unclear Ibrutinib [1]
MR012963 Ibrutinib PCI-45227 (M37) Multi-steps Reaction - Epoxidation; hydrolyzation Ibrutinib [2]
MR012956 Ibrutinib PCI-45741 (M25) Multi-steps Reaction - Dehydrogenation; hydroxylation; reduction; oxidation Ibrutinib [2]
MR012958 Ibrutinib PCI-45752 (M34) Unclear Ibrutinib [2]
MR012954 Ibrutinib PCI-45773 (M35) Oxidation - Hydrolyzationn Ibrutinib [2]
MR012946 Ibrutinib PCI-48303 (M26) Conjugation - Glutathione conjugation Ibrutinib [2]
References
1 Extrahepatic metabolism of ibrutinib
2 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.

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