Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR012962)
Formula	ES
	Reactant	Ibrutinib		Product	Desacryl-Ibrutinib
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Esterases (ES)					DME Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012963	Ibrutinib	PCI-45227 (M37)	Multi-steps Reaction - Epoxidation; hydrolyzation	Ibrutinib	[1]
MR012956	Ibrutinib	PCI-45741 (M25)	Multi-steps Reaction - Dehydrogenation; hydroxylation; reduction; oxidation	Ibrutinib	[1]
MR012958	Ibrutinib	PCI-45752 (M34)	Unclear	Ibrutinib	[1]
MR012954	Ibrutinib	PCI-45773 (M35)	Oxidation - Hydrolyzationn	Ibrutinib	[1]
MR012946	Ibrutinib	PCI-48303 (M26)	Conjugation - Glutathione conjugation	Ibrutinib	[1]
MR012961	Ibrutinib	PCI-7503 (M23)	Hydrolysis - Hydrolyzation	Ibrutinib	[1]

References
1	Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.

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