Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012963)
Formula
CYP3A4 ...
SVG example
Epoxidation; hydrolyzation
Reactant Ibrutinib Product PCI-45227 (M37)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Multi-steps Reaction - Epoxidation; hydrolyzation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012962 Ibrutinib Desacryl-Ibrutinib Unclear Ibrutinib [1]
MR012956 Ibrutinib PCI-45741 (M25) Multi-steps Reaction - Dehydrogenation; hydroxylation; reduction; oxidation Ibrutinib [2]
MR012958 Ibrutinib PCI-45752 (M34) Unclear Ibrutinib [2]
MR012954 Ibrutinib PCI-45773 (M35) Oxidation - Hydrolyzationn Ibrutinib [2]
MR012946 Ibrutinib PCI-48303 (M26) Conjugation - Glutathione conjugation Ibrutinib [2]
MR012961 Ibrutinib PCI-7503 (M23) Hydrolysis - Hydrolyzation Ibrutinib [2]
References
1 Extrahepatic metabolism of ibrutinib
2 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.

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