Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013308)
Formula
SVG example
Reactant E-3A Product 17beta-Estradiol-3,17-beta-sulfate
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013329 E-3A 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) Unclear E-3A [1]
MR013326 E-3A 17-beta-Estradiol glucuronide Unclear E-3A [2], [3]
MR013324 E-3A 17-beta-Estradiol-3-glucuronide Unclear E-3A [1]
MR013327 E-3A 17alpha-Estradiol-3-glucuronide Unclear E-3A [1]
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [4]
MR013325 E-3A 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) Unclear E-3A [2]
MR013323 E-3A 2-Methoxyestrone 3-glucuronide Unclear E-3A [4]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [5]
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [5]
MR013328 E-3A Estradiol-17alpha 3-D-glucuronoside Unclear E-3A [1]
MR013322 E-3A Estradiol-17beta 3-sulfate Unclear E-3A [6]
MR013320 E-3A Estrone Unclear E-3A [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002624 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol acetate [7]
MR002647 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol cypionate [7]
MR002670 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol valerate [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013309 17Beta-Estradiol-3,17-beta-sulfate Estrone Unclear E-3A [7]
MR002637 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol acetate [7]
MR002660 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol cypionate [7]
MR002683 17beta-Estradiol-3,17-beta-sulfate Estrone Unclear Estradiol valerate [7]
References
1 DrugBank(Pharmacology-Metabolism):E-3A
2 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
3 Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry Anal Chem. 2009 Dec 15;81(24):10143-8. doi: 10.1021/ac9019126.
4 DrugBank(Pharmacology-Metabolism)Estradiol acetate
5 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
6 FOODB:E-3A
7 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.

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