Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013326)
Formula
SVG example
Reactant E-3A Product 17-beta-Estradiol glucuronide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013329 E-3A 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) Unclear E-3A [1]
MR013324 E-3A 17-beta-Estradiol-3-glucuronide Unclear E-3A [1]
MR013327 E-3A 17alpha-Estradiol-3-glucuronide Unclear E-3A [1]
MR013308 E-3A 17beta-Estradiol-3,17-beta-sulfate Unclear E-3A [2]
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [3]
MR013325 E-3A 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) Unclear E-3A [4]
MR013323 E-3A 2-Methoxyestrone 3-glucuronide Unclear E-3A [3]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [5]
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [5]
MR013328 E-3A Estradiol-17alpha 3-D-glucuronoside Unclear E-3A [1]
MR013322 E-3A Estradiol-17beta 3-sulfate Unclear E-3A [6]
MR013320 E-3A Estrone Unclear E-3A [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002631 Estradiol 17-beta-Estradiol glucuronide Unclear Estradiol acetate [4], [7]
MR002655 Estradiol 17-beta-Estradiol glucuronide Unclear Estradiol cypionate [4]
MR002678 Estradiol 17-beta-Estradiol glucuronide Unclear Estradiol valerate [4]
References
1 DrugBank(Pharmacology-Metabolism):E-3A
2 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
3 DrugBank(Pharmacology-Metabolism)Estradiol acetate
4 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
5 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
6 FOODB:E-3A
7 Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry Anal Chem. 2009 Dec 15;81(24):10143-8. doi: 10.1021/ac9019126.

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