Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00806)
Xenobiotics Name
Aflatoxin B1
Xenobiotics Type
Health or Environmental Toxicant(s)
Classification
Carcinogen
Structure
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3D MOL 2D MOL
PubChem CID
186907
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acyl-CoA thioesterase 2 (ACOT2) DME Info Homo sapiens [1]
Acetyl-CoA synthetase (ACSS2) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-I alpha (ADH1A) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-I beta (ADH1B) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-I gamma (ADH1C) DME Info Homo sapiens [2]
Alcohol dehydrogenase class-II (ADH4) DME Info Homo sapiens [1], [2]
Alcohol dehydrogenase class-V (ADH6) DME Info Homo sapiens [2]
Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DME Info Homo sapiens [1], [2]
Aldo-keto reductase 1A1 (AKR1A1) DME Info Homo sapiens [2]
Aldo-keto reductase 1C4 (AKR1C4) DME Info Homo sapiens [1], [2]
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [2]
Porphobilinogen synthase (ALAD) DME Info Homo sapiens [1]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [2]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DME Info Homo sapiens [2]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [2]
Alanyl aminopeptidase (ANPEP) DME Info Homo sapiens [2]
Aquaporin adipose (AQP7) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [1], [3]
Bile acid-CoA thioesterase (BAAT) DME Info Homo sapiens [1]
Cytosolic branched aminotransferase (BCAT1) DME Info Homo sapiens [4], [3]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1], [2]
Catalase (CAT) DME Info Homo sapiens [5]
Carboxylesterase 2 (CES2) DME Info Homo sapiens [2]
Choline dehydrogenase (CHDH) DME Info Homo sapiens [2]
Microsomal cytochrome MCB5 (CYB5A) DME Info Homo sapiens [1], [2]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Vitamin D(3) 25-hydroxylase (CYP27A1) DME Info Homo sapiens [2]
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [2]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1], [2]
Cytochrome P450 2C8 (CYP2C8) DME Info Homo sapiens [1], [2]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1], [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [1], [2]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [1]
Lauric acid omega-hydroxylase (CYP4A11) DME Info Homo sapiens [1]
Cytochrome P450 4F12 (CYP4F12) DME Info Homo sapiens [2]
Cytochrome P450 4F2 (CYP4F2) DME Info Homo sapiens [2]
Dicarbonyl/L-xylulose reductase (DCXR) DME Info Homo sapiens [1]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
Delta(24)-sterol reductase (DHCR24) DME Info Homo sapiens [2]
Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DME Info Homo sapiens [2]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [4], [3]
Bifunctional epoxide hydrolase 2 (EPHX2) DME Info Homo sapiens [1], [2]
Fatty acid desaturase 1 (FADS1) DME Info Homo sapiens [2]
Fatty acid desaturase 2 (FADS2) DME Info Homo sapiens [2]
Dimethylaniline oxidase 3 (FMO3) DME Info Homo sapiens [1], [2]
Glutathione S-transferase alpha-1 (GSTA1) DME Info Homo sapiens [4], [3]
Glutathione S-transferase alpha-2 (GSTA2) DME Info Homo sapiens [4], [1]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [1], [2]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [4], [2]
Histamine N-methyltransferase (HNMT) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [1], [2]
Dihydrotestosterone oxidoreductase (HSD3B1) DME Info Homo sapiens [1]
Kynurenine aminotransferase I (KYAT1) DME Info Homo sapiens [1]
S-adenosylmethionine synthase 1 (MAT1A) DME Info Homo sapiens [2]
Neprilysin (MME) DME Info Homo sapiens [2]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1], [2]
Peptide methionine sulfoxide reductase (MSRA) DME Info Homo sapiens [4], [2]
Methionine-R-sulfoxide reductase B1 (MSRB1) DME Info Homo sapiens [1]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [2]
N-acetyltransferase 2 (NAT2) DME Info Homo sapiens [1]
Phosphorylethanolamine transferase (PCYT2) DME Info Homo sapiens [2]
Phosphoglucomutase 1 (PGM1) DME Info Homo sapiens [2]
Serum paraoxonase/arylesterase 1 (PON1) DME Info Homo sapiens [2]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [2]
Xylosyl phosphatase (PXYLP1) DME Info Homo sapiens [2]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [1]
Sulfotransferase 1A1 (SULT1A1) DME Info Homo sapiens [7], [2]
Sulfotransferase 1B1 (SULT1B1) DME Info Homo sapiens [1], [2]
Sulfotransferase 2A1 (SULT2A1) DME Info Homo sapiens [1]
Tryptophan oxygenase (TRPO) DME Info Homo sapiens [1]
Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DME Info Homo sapiens [1]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Tartrate-resistant acid ATPase (ACP5) DME Info Homo sapiens [4]
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [1], [2]
Arachidonate 12-lipoxygenase (ALOX12B) DME Info Homo sapiens [1]
Arachidonate 5-lipoxygenase (ALOX5) DME Info Homo sapiens [1]
Cytidine aminohydrolase (CDA) DME Info Homo sapiens [2]
Aromatase (CYP19A1) DME Info Homo sapiens [8]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [7]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [4]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [4]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [4]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [1]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [3]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [4], [3]
Hexosephosphate aminotransferase 2 (GFPT2) DME Info Homo sapiens [1]
L-glutamine amidohydrolase (GLS) DME Info Homo sapiens [4]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [4]
Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DME Info Homo sapiens [9]
Iduronate 2-sulfatase (IDS) DME Info Homo sapiens [4], [2]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [2]
S-adenosylmethionine synthase 2 (MAT2A) DME Info Homo sapiens [2]
Metallothionein-1A (MT1A) DME Info Homo sapiens [1], [5]
Metallothionein-2A (MT2A) DME Info Homo sapiens [2]
Cysteinyl-conjugate N-acetyltransferase (NAT8) DME Info Homo sapiens [4], [3]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [4]
Purine nucleoside phosphorylase (PNP) DME Info Homo sapiens [1], [2]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [10]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [4]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
Sulfotransferase 1C4 (SULT1C4) DME Info Homo sapiens [2], [3]
Transglutaminase K (TGM1) DME Info Homo sapiens [4]
Transglutaminase H (TGM2) DME Info Homo sapiens [2]
Transglutaminase X (TGM5) DME Info Homo sapiens [4], [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [1], [2]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info Homo sapiens [7]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [2]
UDP-glucuronosyltransferase 2B10 (UGT2B10) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info Homo sapiens [4]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [4], [1]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [2]
References
1 Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87.
2 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
3 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
4 Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol Lett. 2011 Aug 28;205(2):146-53.
5 Zinc inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in human hepatocytes (HepG2 cells). Food Chem Toxicol. 2016 Jun;92:17-25.
6 Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. Drug Metab Dispos. 2008 Jun;36(6):1111-8.
7 Adipose tissue stem cell-derived hepatic progenies as an in vitro model for genotoxicity testing. Arch Toxicol. 2018 May;92(5):1893-1903.
8 Aflatoxin B1--a potential endocrine disruptor--up-regulates CYP19A1 in JEG-3 cells. Toxicol Lett. 2011 May 10;202(3):161-7.
9 The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells. Toxicol Lett. 2013 Apr 26;218(3):200-6.
10 Aflatoxin B1 disrupts transient receptor potential channel activity and increases COX-2 expression in JEG-3 placental cells. Chem Biol Interact. 2016 Dec 25;260:84-90.

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