Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01291)
Xenobiotics Name
Esculetin
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Preclinical/Patented Drug
Structure
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3D MOL 2D MOL
PubChem CID
5281416
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [1]
Ampc beta-lactamase (ampC) DME Info Burkholderia cenocepacia [2]
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [2]
Azoreductase (azoR) DME Info Escherichia coli [3]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [3]
Beta-lactamase (blaB) DME Info Escherichia coli [3]
Chloramphenicolase (chlR) DME Info Escherichia coli [3]
Glycoside hydrolase (cscA) DME Info Escherichia coli [3]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [3]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [3]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [3]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [3]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [4]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [3]
Glutamate racemase (MurI) DME Info Escherichia coli [3]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [4]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [3]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [3]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [3]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [3]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [2]
Beta-lactamase (blaB) DME Info Burkholderia cenocepacia [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [4]
Tyramine oxidase (tynA) DME Info Escherichia coli [3]
Beta-glucuronidase (uidA) DME Info Escherichia coli [3]
DME(s) Induced by This Xenobiotics
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
References
1 Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. Chem Biol Interact. 2018 Oct 1;294:158-166.
2 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
3 Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus. Appl Microbiol Biotechnol. 2014 Nov;98(22):9447-57.
4 Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl Microbiol Biotechnol. 2008 May;79(1):119-26.
5 Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):130-6.

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