Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1072)
DME Name Cytochrome P450 MEG (cyp106), Bacillus megaterium DME Info
UniProt ID
CPXM_BACME
EC Number    EC: 1.14.15.8     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.8
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Subspecies: Bacillus megaterium ATCC 13368
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Progesterone Click to Show/Hide the Full List of HOSPPI:      15 HOSPPI
                            Aldo-keto reductase 1C1 (AKR1C1) Click to Show/Hide the Cometabolization Info
DME ID DME0197 DME Info
Uniprot ID
AK1C1_HUMAN
Interaction Name AKR1C1-cyp106 interaction [1], [2]
Description The interaction, between human Aldo-keto reductase 1C1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp106 interaction [1], [6]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp106 interaction [1], [7]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1B1 (CYP1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0023 DME Info
Uniprot ID
CP1B1_HUMAN
Interaction Name CYP1B1-cyp106 interaction [1], [8]
Description The interaction, between human Cytochrome P450 1B1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A6 (CYP2A6) Click to Show/Hide the Cometabolization Info
DME ID DME0005 DME Info
Uniprot ID
CP2A6_HUMAN
Interaction Name CYP2A6-cyp106 interaction [1], [10]
Description The interaction, between human Cytochrome P450 2A6 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp106 interaction [1], [14]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-cyp106 interaction [1], [15]
Description The interaction, between human Cytochrome P450 2D6 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp106 interaction [1], [17]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp106 interaction [1], [20]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp106 interaction [1], [22]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 4B1 (CYP4B1) Click to Show/Hide the Cometabolization Info
DME ID DME0010 DME Info
Uniprot ID
CP4B1_HUMAN
Interaction Name CYP4B1-cyp106 interaction [1], [23]
Description The interaction, between human Cytochrome P450 4B1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Glutathione S-transferase alpha-1 (GSTA1) Click to Show/Hide the Cometabolization Info
DME ID DME0011 DME Info
Uniprot ID
GSTA1_HUMAN
Interaction Name GSTA1-cyp106 interaction [1], [26]
Description The interaction, between human Glutathione S-transferase alpha-1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp106 interaction [1], [14]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 21-hydroxylase (CYP21A2) Click to Show/Hide the Cometabolization Info
DME ID DME0037 DME Info
Uniprot ID
CP21A_HUMAN
Interaction Name CYP21A2-cyp106 interaction [1], [27]
Description The interaction, between human Steroid 21-hydroxylase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Sulfotransferase 1A1 (SULT1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0008 DME Info
Uniprot ID
ST1A1_HUMAN
Interaction Name SULT1A1-cyp106 interaction [1], [29]
Description The interaction, between human Sulfotransferase 1A1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Progesterone, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Testosterone cypionate Click to Show/Hide the Full List of HOSPPI:      19 HOSPPI
                            Aromatase (CYP19A1) Click to Show/Hide the Cometabolization Info
DME ID DME0002 DME Info
Uniprot ID
CP19A_HUMAN
Interaction Name CYP19A1-cyp106 interaction [3], [4], [5]
Description The interaction, between human Aromatase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp106 interaction [3], [4], [6]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp106 interaction [3], [4], [7]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1B1 (CYP1B1) Click to Show/Hide the Cometabolization Info
DME ID DME0023 DME Info
Uniprot ID
CP1B1_HUMAN
Interaction Name CYP1B1-cyp106 interaction [3], [4], [8]
Description The interaction, between human Cytochrome P450 1B1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2A13 (CYP2A13) Click to Show/Hide the Cometabolization Info
DME ID DME0030 DME Info
Uniprot ID
CP2AD_HUMAN
Interaction Name CYP2A13-cyp106 interaction [3], [4], [9]
Description The interaction, between human Cytochrome P450 2A13 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp106 interaction [3], [4], [11]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp106 interaction [3], [4], [12]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp106 interaction [3], [4], [13]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp106 interaction [3], [4], [16]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A43 (CYP3A43) Click to Show/Hide the Cometabolization Info
DME ID DME0022 DME Info
Uniprot ID
CP343_HUMAN
Interaction Name CYP3A43-cyp106 interaction [3], [4], [18]
Description The interaction, between human Cytochrome P450 3A43 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A5 (CYP3A5) Click to Show/Hide the Cometabolization Info
DME ID DME0012 DME Info
Uniprot ID
CP3A5_HUMAN
Interaction Name CYP3A5-cyp106 interaction [3], [4], [19]
Description The interaction, between human Cytochrome P450 3A5 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A7 (CYP3A7) Click to Show/Hide the Cometabolization Info
DME ID DME0015 DME Info
Uniprot ID
CP3A7_HUMAN
Interaction Name CYP3A7-cyp106 interaction [3], [4], [21]
Description The interaction, between human Cytochrome P450 3A7 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 4B1 (CYP4B1) Click to Show/Hide the Cometabolization Info
DME ID DME0010 DME Info
Uniprot ID
CP4B1_HUMAN
Interaction Name CYP4B1-cyp106 interaction [3], [4], [23]
Description The interaction, between human Cytochrome P450 4B1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Dehydrogenase/reductase retSDR3 (HSD17B14) Click to Show/Hide the Cometabolization Info
DME ID DME0609 DME Info
Uniprot ID
DHB14_HUMAN
Interaction Name HSD17B14-cyp106 interaction [3], [4], [24]
Description The interaction, between human Dehydrogenase/reductase retSDR3 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Farnesol dehydrogenase (AKR1B15) Click to Show/Hide the Cometabolization Info
DME ID DME0399 DME Info
Uniprot ID
AK1BF_HUMAN
Interaction Name AKR1B15-cyp106 interaction [3], [4], [25]
Description The interaction, between human Farnesol dehydrogenase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp106 interaction [3], [4], [14]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 1 (SRD5A1) Click to Show/Hide the Cometabolization Info
DME ID DME0204 DME Info
Uniprot ID
S5A1_HUMAN
Interaction Name SRD5A1-cyp106 interaction [3], [4], [28]
Description The interaction, between human Steroid 5-alpha-reductase 1 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 2 (SRD5A2) Click to Show/Hide the Cometabolization Info
DME ID DME0218 DME Info
Uniprot ID
S5A2_HUMAN
Interaction Name SRD5A2-cyp106 interaction [3], [4], [28]
Description The interaction, between human Steroid 5-alpha-reductase 2 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Steroid 5-alpha-reductase 3 (SRD5A3) Click to Show/Hide the Cometabolization Info
DME ID DME0219 DME Info
Uniprot ID
PORED_HUMAN
Interaction Name SRD5A3-cyp106 interaction [3], [4], [28]
Description The interaction, between human Steroid 5-alpha-reductase 3 and Cytochrome P450 MEG from Bacillus megaterium which collectively metabolize the drug Testosterone cypionate, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
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2 Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43.
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4 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
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6 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
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11 Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
12 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
13 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
14 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
15 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
16 Digging deeper into CYP3A testosterone metabolism: kinetic, regioselectivity, and stereoselectivity differences between CYP3A4/5 and CYP3A7. Drug Metab Dispos. 2017 Dec;45(12):1266-1275.
17 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
18 cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol. 2001 Feb;59(2):386-92.
19 In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44.
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22 The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
23 Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6.
24 Expression patterns of 17beta-hydroxysteroid dehydrogenase 14 in human tissues. Horm Metab Res. 2012 Dec;44(13):949-56.
25 Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45.
26 Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
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29 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.

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