Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1098)
DME Name Oxygen-insensitive NADPH nitroreductase A (nfsA), Escherichia coli DME Info
UniProt ID
NFSA_ECOLI
EC Number    EC: 1.5.1.38     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.38
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Loperamide hydrochloride Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-nfsA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2B6 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Loperamide hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-nfsA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2C8 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Loperamide hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-nfsA interaction [1], [2]
Description The interaction, between human Cytochrome P450 2D6 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Loperamide hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-nfsA interaction [1], [6]
Description The interaction, between human Cytochrome P450 3A4 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Loperamide hydrochloride, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nitrofural Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 2D6 (CYP2D6) Click to Show/Hide the Cometabolization Info
DME ID DME0009 DME Info
Uniprot ID
CP2D6_HUMAN
Interaction Name CYP2D6-nfsA interaction [3], [4]
Description The interaction, between human Cytochrome P450 2D6 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Nitrofural, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: Nitrazepam Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-nfsA interaction [3], [5]
Description The interaction, between human Cytochrome P450 3A4 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug Nitrazepam, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
               Cometabolized drug: CBL-954 Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                            Quinone reductase 1 (NQO1) Click to Show/Hide the Cometabolization Info
DME ID DME0097 DME Info
Uniprot ID
NQO1_HUMAN
Interaction Name NQO1-nfsA interaction [7], [8]
Description The interaction, between human Quinone reductase 1 and Oxygen-insensitive NADPH nitroreductase A from Escherichia coli which collectively metabolize the drug CBL-954, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. Drug Metab Dispos. 1995 Mar;23(3):354-62.
2 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81.
3 Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase. J Bacteriol. 1996 Aug;178(15):4508-14.
4 Nefazodone pharmacokinetics in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry. 2000 Aug;39(8):1008-16.
5 Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica. 2008 Apr;38(4):353-67.
6 Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8.
7 Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87.
8 Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301

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