Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0006)
DME Name Cytochrome P450 1A1 (CYP1A1), Homo sapiens DME Info
UniProt ID
CP1A1_HUMAN
EC Number    EC: 1.14.14.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Flavin/flavoprotein donor oxidoreductase
EC: 1.14.14.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bifidobacterium ruminatum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [4], [5]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Streptomyces avermitilis co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [7], [4]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Alistipes indistinctus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides caccae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              NAB-365 Click to Show/Hide the Detail
                                 Drug ID DR0338   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides caccae co-metabolize the drug NAB-365, which can collectively affect efficacy, safety or bioavailability of this drug. [8], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides caccae co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides coprophilus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [10]
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides dorei co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides dorei co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides eggerthii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides fragilis co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides fragilis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides ovatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides ovatus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides sartorii co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides sartorii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides stercoris co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides stercoris co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides thetaiotaomicron co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides thetaiotaomicron co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides vulgatus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides vulgatus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides xylanisolvens co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacteroides xylanisolvens co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Odoribacter splanchnicus co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Odoribacter splanchnicus co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Parabacteroides distasonis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Prevotella copri co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus megaterium co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [12]
                              Amodiaquine Click to Show/Hide the Detail
                                 Drug ID DR0102   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus megaterium co-metabolize the drug Amodiaquine, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [12]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [14]
                              Progesterone Click to Show/Hide the Detail
                                 Drug ID DR1346   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [15]
                              Testosterone cypionate Click to Show/Hide the Detail
                                 Drug ID DR1564   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus megaterium co-metabolize the drug Testosterone cypionate, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [15], [16]
                  Bacillus subtilis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Bacillus subtilis co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [18]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Blautia hansenii co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Clostridioides difficile co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [19]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Procarbazine Click to Show/Hide the Detail
                                 Drug ID DR1344   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Clostridium botulinum co-metabolize the drug Procarbazine, which can collectively affect efficacy, safety or bioavailability of this drug. [9], [2]
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Clostridium botulinum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Clostridium sporogenes co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Enterococcus faecalis co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [19]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Erysipelatoclostridium ramosum co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [10]
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Faecalibacterium prausnitzii co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [21]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Lactobacillus reuteri co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [10]
                  Lactobacillus sakei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Erythromycin stearate Click to Show/Hide the Detail
                                 Drug ID DR0614   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Lactobacillus sakei co-metabolize the drug Erythromycin stearate, which can collectively affect efficacy, safety or bioavailability of this drug. [22], [23], [24]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Roseburia intestinalis co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [3], [10]
                  Staphylococcus aureus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Staphylococcus aureus co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [25]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Subdoligranulum variabile co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Proteobacteria
                  Citrobacter freundii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Citrobacter freundii co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [19]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Escherichia coli co-metabolize the drug Acetaminophen, which can collectively affect efficacy, safety or bioavailability of this drug. [11], [19]
                  Pseudomonas putida (gamma-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Nicotine Click to Show/Hide the Detail
                                 Drug ID DR1148   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Pseudomonas putida co-metabolize the drug Nicotine, which can collectively affect efficacy, safety or bioavailability of this drug. [26], [27]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Menadione Click to Show/Hide the Detail
                                 Drug ID DR1022   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Salmonella enterica co-metabolize the drug Menadione, which can collectively affect efficacy, safety or bioavailability of this drug. [20], [28], [29]
                  Salmonella typhimurium (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Salmonella typhimurium co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [28], [30]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riluzole Click to Show/Hide the Detail
                                 Drug ID DR1425   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) and Akkermansia muciniphila co-metabolize the drug Riluzole, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Fungi: Ascomycota
                  Saccharomyces cerevisiae (ascomycota) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Acetaminophen Click to Show/Hide the Detail
                                 Drug ID DR0037   Drug Info
                                 Interaction Mechanism Human Cytochrome P450 1A1 (CYP1A1) metabolizes the drug Acetaminophen, and Saccharomyces cerevisiae further metabolizes its metabolite (1-Phenyl-1,2-propanedione), which can indirectly affect efficacy, safety or bioavailability of this drug. [11], [19]
References
1 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
4 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
5 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
6 Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
7 Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis. Biochem Biophys Res Commun. 2020 Feb 5;522(2):355-361.
8 Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50.
9 In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805.
10 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
11 Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7.
12 The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
13 Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407.
14 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
15 acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
16 A Novel NADPH-dependent flavoprotein reductase from Bacillus megaterium acts as an efficient cytochrome P450 reductase. J Biotechnol. 2016 Aug 10;231:83-94.
17 Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81.
18 Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5.
19 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
20 Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8.
21 Quinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20;5(1):161.
22 Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72.
23 Identification of Lactobacillus sakei genes induced during meat fermentation and their role in survival and growth. Appl Environ Microbiol. 2007 Apr;73(8):2522-31.
24 Degradation of various insecticides in cooked eggs during in vitro human digestion. Environ Pollut. 2018 Dec;243(Pt A):437-443.
25 Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500.
26 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
27 Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
28 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
29 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
30 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter

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