Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0040)
DME Name UDP-glucuronosyltransferase 2B7 (UGT2B7), Homo sapiens DME Info
UniProt ID
UD2B7_HUMAN
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium adolescentis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium adolescentis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium breve (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium breve co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium breve co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium longum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium longum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium longum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bifidobacterium ruminatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium ruminatum co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bifidobacterium ruminatum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Collinsella aerofaciens (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Pitavastatin calcium Click to Show/Hide the Detail
                                 Drug ID DR1306   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Collinsella aerofaciens co-metabolize the drug Pitavastatin calcium, which can collectively affect efficacy, safety or bioavailability of this drug. [6], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Collinsella aerofaciens co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                  Collinsella intestinalis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Collinsella intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Eggerthella lenta (actinobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Eggerthella lenta co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Eggerthella lenta co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Streptomyces avermitilis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Streptomyces avermitilis co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [8], [9]
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Alistipes indistinctus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides cellulosilyticus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides cellulosilyticus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bacteroides coprophilus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides coprophilus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides coprophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides dorei (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides dorei co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Diclofenac sodium, and Bacteroides dorei further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [11]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides dorei co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides dorei co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides dorei co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides dorei co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides eggerthii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides eggerthii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides fragilis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides fragilis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides intestinalis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides intestinalis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides ovatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides ovatus co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides ovatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides sartorii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides sartorii co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides stercoris (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides stercoris co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides stercoris co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides stercoris co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides thetaiotaomicron (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides thetaiotaomicron co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides uniformis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides uniformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides uniformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacteroides vulgatus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        6 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Indomethacin, and Bacteroides vulgatus further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [14], [15]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides vulgatus co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides vulgatus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides vulgatus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides vulgatus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides vulgatus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Bacteroides xylanisolvens (CFB bacteria) Click to Show/Hide the Full List of Drugs:        9 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides xylanisolvens co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Odoribacter splanchnicus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        7 Drugs Metabolized
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Odoribacter splanchnicus co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Parabacteroides distasonis (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides distasonis co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides distasonis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides distasonis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Naproxen Click to Show/Hide the Detail
                                 Drug ID DR1130   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides distasonis co-metabolize the drug Naproxen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                  Parabacteroides johnsonii (CFB bacteria) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides johnsonii co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides johnsonii co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides johnsonii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Parabacteroides merdae (CFB bacteria) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides merdae co-metabolize the drug Indomethacin, which can collectively affect efficacy, safety or bioavailability of this drug. [14], [2]
                              Losartan potassium Click to Show/Hide the Detail
                                 Drug ID DR0984   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides merdae co-metabolize the drug Losartan potassium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides merdae co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Parabacteroides merdae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Prevotella copri co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Prevotella copri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Anaerobutyricum hallii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Anaerococcus hydrogenalis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Anaerococcus hydrogenalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                              Zidovudine Click to Show/Hide the Detail
                                 Drug ID DR1729   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Anaerococcus hydrogenalis co-metabolize the drug Zidovudine, which can collectively affect efficacy, safety or bioavailability of this drug. [7], [2]
                  Anaerostipes hadrus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Anaerostipes hadrus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Bacillus megaterium (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacillus megaterium co-metabolize the drug Diclofenac sodium, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [16]
                  Bacillus pumilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Gemfibrozil Click to Show/Hide the Detail
                                 Drug ID DR0766   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacillus pumilus co-metabolize the drug Gemfibrozil, which can collectively affect efficacy, safety or bioavailability of this drug. [17], [18]
                  Bacteroides pectinophilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Bacteroides pectinophilus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Blautia hansenii (firmicutes) Click to Show/Hide the Full List of Drugs:        4 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Blautia hansenii co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Blautia hansenii co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Etodolac Click to Show/Hide the Detail
                                 Drug ID DR0666   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Blautia hansenii co-metabolize the drug Etodolac, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Blautia hansenii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Blautia luti (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Blautia luti co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridioides difficile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridioides difficile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridium botulinum (firmicutes) Click to Show/Hide the Full List of Drugs:        5 Drugs Metabolized
                              Anastrozole Click to Show/Hide the Detail
                                 Drug ID DR0113   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium botulinum co-metabolize the drug Anastrozole, which can collectively affect efficacy, safety or bioavailability of this drug. [19], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium botulinum co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                              Ketorolac Click to Show/Hide the Detail
                                 Drug ID DR0908   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium botulinum co-metabolize the drug Ketorolac, which can collectively affect efficacy, safety or bioavailability of this drug. [12], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium botulinum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium botulinum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridium perfringens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium perfringens co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Clostridium scindens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium scindens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridium spiroforme (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium spiroforme co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Clostridium sporogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium sporogenes co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Ezetimibe Click to Show/Hide the Detail
                                 Drug ID DR0677   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Clostridium sporogenes co-metabolize the drug Ezetimibe, which can collectively affect efficacy, safety or bioavailability of this drug. [13], [2]
                  Coprococcus comes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Coprococcus comes co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Dorea formicigenerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Dorea formicigenerans co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterocloster asparagiformis (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Enterocloster asparagiformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Enterocloster asparagiformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterocloster bolteae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Enterocloster bolteae co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterococcus faecalis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Enterococcus faecalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Erysipelatoclostridium ramosum (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Indomethacin, and Erysipelatoclostridium ramosum further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [14], [15]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Erysipelatoclostridium ramosum co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Eubacterium limosum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Eubacterium limosum co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Eubacterium rectale (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Eubacterium rectale co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Faecalibacterium prausnitzii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Diclofenac sodium, and Faecalibacterium prausnitzii further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [11]
                  Holdemanella biformis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Holdemanella biformis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Holdemanella biformis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Holdemanella biformis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Hungatella hathewayi (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Hungatella hathewayi co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Lactobacillus reuteri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Lactobacillus rhamnosus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Diclofenac sodium, and Lactobacillus rhamnosus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [11]
                  Marvinbryantia formatexigens (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Marvinbryantia formatexigens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Roseburia hominis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Indomethacin, and Roseburia hominis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [14], [15]
                  Roseburia intestinalis (firmicutes) Click to Show/Hide the Full List of Drugs:        3 Drugs Metabolized
                              Carvedilol Click to Show/Hide the Detail
                                 Drug ID DR0282   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Roseburia intestinalis co-metabolize the drug Carvedilol, which can collectively affect efficacy, safety or bioavailability of this drug. [10], [2]
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Indomethacin, and Roseburia intestinalis further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [14], [15]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Roseburia intestinalis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Ruminococcus gnavus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Diclofenac sodium Click to Show/Hide the Detail
                                 Drug ID DR0488   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Diclofenac sodium, and Ruminococcus gnavus further metabolizes its metabolite (Diclofenac glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [5], [11]
                  Ruminococcus torques (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Ruminococcus torques co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Subdoligranulum variabile (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Subdoligranulum variabile co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Fusobacteria
                  Fusobacterium varium (fusobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Fusobacterium varium co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Lovastatin Click to Show/Hide the Detail
                                 Drug ID DR0986   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Victivallis vadensis co-metabolize the drug Lovastatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Victivallis vadensis co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
      Bacteria: Proteobacteria
                  Edwardsiella tarda (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Edwardsiella tarda co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Enterobacter cancerogenus (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Enterobacter cancerogenus co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Indomethacin Click to Show/Hide the Detail
                                 Drug ID DR0875   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) metabolizes the drug Indomethacin, and Escherichia coli further metabolizes its metabolite (Indomethacin glucuronide), which can indirectly affect efficacy, safety or bioavailability of this drug. [14], [20]
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Escherichia coli co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Proteus penneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Proteus penneri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia alcalifaciens (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Providencia alcalifaciens co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia rettgeri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Providencia rettgeri co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Providencia stuartii (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Providencia stuartii co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Salmonella enterica (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Salmonella enterica co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
                  Sphingomonas colocasiae (alpha-proteobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Ibuprofen Click to Show/Hide the Detail
                                 Drug ID DR0844   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Sphingomonas colocasiae co-metabolize the drug Ibuprofen, which can collectively affect efficacy, safety or bioavailability of this drug. [5], [21]
      Bacteria: Verrucomicrobia
                  Akkermansia muciniphila (verrucomicrobiae) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Mycophenolate mofetil Click to Show/Hide the Detail
                                 Drug ID DR1118   Drug Info
                                 Interaction Mechanism Human UDP-glucuronosyltransferase 2B7 (UGT2B7) and Akkermansia muciniphila co-metabolize the drug Mycophenolate mofetil, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
References
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2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.
4 In vitro susceptibility of cultured human methanogens to lovastatin. Int J Antimicrob Agents. 2017 Feb;49(2):176-182.
5 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
6 Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168.
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8 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
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10 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
11 tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825.
12 Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. Br J Clin Pharmacol. 2017 Sep;83(9):1966-1975.
13 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
14 Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96.
15 Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
16 Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753.
17 The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4.
18 Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55.
19 In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69.
20 Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.
21 Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2. Microbiology. 2013 Mar;159(Pt 3):621-632.

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