Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0403)
DME Name Arachidonate 15-lipoxygenase (ALOX15), Homo sapiens DME Info
UniProt ID
LOX15_HUMAN
EC Number    EC: 1.13.11.33     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.33
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Caffeic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01232   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Caffeic acid inhibits the drug-metabolizing activity of DME ALOX15 [1]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Baicalein Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01212   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Baicalein inhibits the drug-metabolizing activity of DME ALOX15 [2]
                              Honokiol Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01332   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Honokiol induces the drug-metabolizing activity of DME ALOX15 [3]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Acetaminophen Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00217   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetaminophen inhibits the expression of DME ALOX15 [4]
                              Sodium fluoride F-18 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00422   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sodium fluoride F-18 induces the drug-metabolizing activity of DME ALOX15 [5]
                              Sulindac Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00177   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Sulindac up-regulates the expression of DME ALOX15 [6]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the expression of DME ALOX15 [7]
                              Triclosan Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00560   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Triclosan induces the drug-metabolizing activity of DME ALOX15 [8]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              CP-461 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01082   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation CP-461 induces the drug-metabolizing activity of DME ALOX15 [9]
                              Sulindac sulfide Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00656   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Sulindac sulfide induces the drug-metabolizing activity of DME ALOX15 [10]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              NS-398 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00583   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation NS-398 up-regulates the expression of DME ALOX15 [11]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 up-regulates the expression of DME ALOX15 [12]
                              Esculetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01291   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Esculetin inhibits the drug-metabolizing activity of DME ALOX15 [13]
                              YC-1 Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO01131   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation YC-1 induces the drug-metabolizing activity of DME ALOX15 [9]
References
1 Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 2001 Jun 15;61(12):4879-84.
2 Evaluation of the antioxidative properties of lipoxygenase inhibitors. Pharmacol Rep. 2012;64(5):1179-88.
3 Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Br J Pharmacol. 2010 Aug;160(8):1963-72.
4 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
5 Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-B signalings in colorectal cancer cells. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):232-9.
6 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142.
7 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
8 Trichloroethylene induce nitric oxide production and nitric oxide synthase mRNA expression in cultured normal human epidermal keratinocytes. Toxicology. 2007 Oct 8;239(3):186-94.
9 Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. Cancer Res. 2005 Sep 15;65(18):8442-7.
10 Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609). Drug Metab Dispos. 2008 Dec;36(12):2556-63.
11 An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 2013 Aug 15;271(1):64-71.
12 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
13 Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells. Chem Biol Interact. 2018 Oct 1;294:158-166.

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