Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01212)
Xenobiotics Name
Baicalein
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Natural Product
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5281605"></iframe>
3D MOL 2D MOL
PubChem CID
5281605
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Arachidonate 15-lipoxygenase (ALOX15) DME Info Homo sapiens [1]
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [2]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [4], [5]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [3]
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [5]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [5]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [6]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [7]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [7]
N-acetyltransferase 1 (NAT1) DME Info Homo sapiens [8]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [9]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [7]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [10]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [11]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 1A1 (CYP1A1) DME Info Ki = 1.22 microM [3]
Cytochrome P450 1B1 (CYP1B1) DME Info Ki = 0.26 microM [3]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 9.2 microM [6]
References
1 Evaluation of the antioxidative properties of lipoxygenase inhibitors. Pharmacol Rep. 2012;64(5):1179-88.
2 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
3 Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg Med Chem. 2011 May 1;19(9):2842-9.
4 Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chem Res Toxicol. 2010 Dec 20;23(12):1921-35.
5 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
6 Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. Eur J Med Chem. 2017 May 5;131:68-80.
7 Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl Microbiol Biotechnol. 2008 May;79(1):119-26.
8 N-acetyltransferase is involved in baicalein-induced N-acetylation of 2-aminofluorene and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells. In Vivo. 2005 Mar-Apr;19(2):399-405.
9 Baicalein inhibits Staphylococcus aureus biofilm formation and the quorum sensing system in vitro. PLoS One. 2016 Apr 29;11(4):e0153468.
10 Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). Toxicol Lett. 2015 Mar 4;233(2):68-77.
11 Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. Biol Reprod. 2008 Mar;78(3):514-20.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.