Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1312)
DME Name Beta-lactamase (blaB), Burkholderia cenocepacia DME Info
UniProt ID
B8R6A5_9BURK
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia cenocepacia     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia cenocepacia
Subspecies: Burkholderia cenocepacia J2315
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Indole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03644   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Indole inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Cinnamic aldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                              Quinone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01450   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Quinone inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Azithromycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00164   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Azithromycin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                              Tobramycin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05156   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Tobramycin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [2]
                              Ceftazidime hydrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02786   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Ceftazidime hydrate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                              Resveratrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00568   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Resveratrol inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Esculetin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01291   XEOTIC Info Gene Form Protein
                                 Classification Drug in Preclinical Study
                                 DME Modulation Esculetin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Esculin hydrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03324   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Esculin hydrate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                              Farnesol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01298   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Farnesol inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
                              Hamamelitannin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03523   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Hamamelitannin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [2]
                              L-Canavanine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03812   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation L-Canavanine inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cenocepacia [1]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release. Sci Rep. 2016 Feb 1;6:20321.

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