Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1265)
DME Name Unclear metabolic mechanism (DME-unclear), Escherichia coli
Gene Name DME-unclear
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Subspecies: Escherichia coli Nissle 1917
Subspecies: Escherichia coli BW25113
Subspecies: Escherichia coli K-12
Subspecies: Escherichia coli VL8
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        29 Drugs
Bupropion
 Drug Info Approved Nicotine dependence ICD11: 6C4A [1]
Primaquine
 Drug Info Approved Malaria ICD11: 1F40 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Duloxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Ziprasidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Doxorubicin
 Drug Info Approved Breast cancer ICD11: 2C60 [2]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Sulfinpyrazone
 Drug Info Approved Uncontrolled gout ICD11: FA25 [1]
Betamethasone valerate
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ritonavir
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Acetaminophen
 Drug Info Approved Anaesthesia ICD11: 8E22 [3]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Loperamide hydrochloride
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Paclitaxel
 Drug Info Approved Ovarian cancer ICD11: 2C73 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Chloramphenicol
 Drug Info Approved Conjunctivitis ICD11: 9A60 [4]
Fludarabine phosphate
 Drug Info Approved Chronic lymphocytic leukaemia ICD11: 2A82 [5]
Mefloquine hydrochloride
 Drug Info Approved Malaria ICD11: 1F40 [1]
Megestrol acetate
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Fluphenazine decanoate
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Norgestimate
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Quercetin
 Drug Info Phase 4 Hypertriglyceridaemia ICD11: 5C80 [6]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Nicergoline
 Drug Info Phase 4 Acne vulgaris ICD11: ED80 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
Levamisole
 Drug Info Discontinued Ascariasis ICD11: 1F62 [1]
AN-16649
 Drug Info Discontinued Acute lymphoblastic leukemia ICD11: 2B33 [5]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          4 Drugs
VUFB-11502
 Drug Info Preclinical Amebiasis ICD11: 1A36 [7]
Glucotropaeolin
 Drug Info Investigative Infectious cystitis ICD11: GC00 [8]
Sinigrin
 Drug Info Investigative Hepatocellular carcinoma ICD11: 2C12 [8]
Gluconasturtiin
 Drug Info Investigative Prostate cancer ICD11: 2C82 [8]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.
3 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 Jul;69(1):51-59.
4 The effect of low-pressure carbonation on the heat inactivation of Escherichia coli. Biosci Biotechnol Biochem. 2011;75(10):1945-50.
5 Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17.
6 Isolation and identification of quercetin degrading bacteria from human fecal microbes. PLoS One. 2014 Mar 4;9(3):e90531.
7 Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets. J Anim Sci. 2006 Sep;84(9):2367-73. Randomized Controlled Trial
8 Glucosinolate and desulfo-glucosinolate metabolism by a selection of human gut bacteria. Curr Microbiol. 2016 Sep;73(3):442-451.

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