Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1362) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Bacteroides caccae | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Bacteroides caccae (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 15 Drugs | ||||
Terbinafine hydrochloride |
Drug Info | Approved | Pityriasis versicolor | ICD11: 1F2D | [1] |
Apomorphine |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
Levonorgestrel |
Drug Info | Approved | Menorrhagia | ICD11: GA20 | [1] |
Norethindrone acetate |
Drug Info | Approved | Menorrhagia | ICD11: GA20 | [1] |
Doxylamine succinate |
Drug Info | Approved | Insomnia | ICD11: 7A00 | [1] |
Nefazodone |
Drug Info | Approved | Depression | ICD11: 6A71 | [1] |
Riluzole |
Drug Info | Approved | Amyotrophic lateral sclerosis | ICD11: 8B60 | [1] |
Tegaserod |
Drug Info | Approved | Irritable bowel syndrome | ICD11: DD91 | [1] |
Danazol |
Drug Info | Approved | Endometriosis | ICD11: GA10 | [1] |
Sulfasalazine |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
Rimantadine |
Drug Info | Approved | Influenza virus infection | ICD11: 1E30 | [1] |
Paliperidone |
Drug Info | Approved | Bipolar disorder | ICD11: 6A60 | [1] |
Risperidone |
Drug Info | Approved | Schizophrenia | ICD11: 6A20 | [1] |
Rivastigmine tartrate |
Drug Info | Approved | Alzheimer disease | ICD11: 8A20 | [1] |
Aminoglutethimide |
Drug Info | Approved | Cushing syndrome | ICD11: 5A70 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
Milnacipran |
Drug Info | Phase 4 | Asperger syndrome | ICD11: 6A02 | [1] |
Buramate |
Drug Info | Phase 4 | Focal seizure | ICD11: 8A68 | [1] |
| Drugs in Phase 2 Clinical Trial | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
NAB-365 |
Drug Info | Phase 2 | Amyotrophic lateral sclerosis | ICD11: 8B60 | [1] |
ENT-50146 |
Drug Info | Phase 2 | Cocaine addiction | ICD11: 6C45 | [1] |
| Drugs in Phase 1 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
BRN-0498823 |
Drug Info | Phase 1 | Essential hypertension | ICD11: BA00 | [1] |
| Preclinical/investigative Agents | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
EPX-100 |
Drug Info | Preclinical | Dravet syndrome | ICD11: 8A61 | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | ||||
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