Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1366)
DME Name Unclear metabolic mechanism (DME-unclear), Bacteroides eggerthii
Gene Name DME-unclear
Lineage    Species: Bacteroides eggerthii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides eggerthii
Subspecies: Bacteroides eggerthii DSM 20697
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        36 Drugs
Prednisone
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Febuxostat
 Drug Info Approved Hyperuricaemia ICD11: 5C55 [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Digitoxin
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Nateglinide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Betamethasone valerate
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Budesonide
 Drug Info Approved Allergic rhinitis ICD11: CA08 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ritonavir
 Drug Info Approved Human immunodeficiency virus infection ICD11: 1C60 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [1]
Fenofibrate
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Loperamide hydrochloride
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Clopidogrel bisulfate
 Drug Info Approved Acute coronary syndrome ICD11: BA4Z [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Mebendazole
 Drug Info Approved Ascariasis ICD11: 1F62 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Trandolapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Azatadine maleate
 Drug Info Approved Allergic rhinitis ICD11: CA08 [1]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
Methoxsalen
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Ramelteon
 Drug Info Approved Insomnia ICD11: 7A00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Cyproterone acetate
 Drug Info Phase 4 Polycystic ovary syndrome ICD11: 5A80 [1]
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
L-phenylalanine
 Drug Info Phase 4 Phenylketonuria ICD11: 5C50 [2]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BV-ara-U
 Drug Info Phase 3 Human immunodeficiency virus infection ICD11: 1C60 [3]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
TRP-01
 Drug Info Phase 1 Depression ICD11: 6A71 [2]
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
L-tyrosine
 Drug Info Investigative Phenylketonuria ICD11: 5C50 [2]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.
3 Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics. 1997 Feb;7(1):35-43.

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