Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1446)
DME Name Unclear metabolic mechanism (DME-unclear), Parabacteroides johnsonii
Gene Name DME-unclear
Lineage    Species: Parabacteroides johnsonii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides johnsonii
Subspecies: Parabacteroides johnsonii DSM 18315
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        34 Drugs
Linagliptin
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Irbesartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Terbinafine hydrochloride
 Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Colchicine
 Drug Info Approved Uncontrolled gout ICD11: FA25 [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Digitoxin
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Drospirenone
 Drug Info Approved Contraception ICD11: JA65 [1]
Levonorgestrel
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Diltiazem hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Sulfinpyrazone
 Drug Info Approved Uncontrolled gout ICD11: FA25 [1]
Betamethasone valerate
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Budesonide
 Drug Info Approved Allergic rhinitis ICD11: CA08 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [1]
Losartan potassium
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Nizatidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ranitidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Clopidogrel bisulfate
 Drug Info Approved Acute coronary syndrome ICD11: BA4Z [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Diflorasone diacetate
 Drug Info Approved Rosacea ICD11: ED90 [1]
Methoxsalen
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          6 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Pericyazine
 Drug Info Phase 4 Anxiety disorder ICD11: 6B00 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Pidotimod
 Drug Info Phase 4 Pulmonary tuberculosis ICD11: 1B10 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-187709
 Drug Info Phase 3 Psoriasis vulgaris ICD11: EA90 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Levamisole
 Drug Info Discontinued Ascariasis ICD11: 1F62 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
QC-1571
 Drug Info Preclinical Chronic laryngitis ICD11: CA0G [1]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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