Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2423)
Drug Name
Pidotimod
Synonyms
Pidotimod; Pidotimod (INN); Pidotimod [INN]; Pidotimodum; Pidotimodum [INN-Latin]; Pidotomod; Pigitil; Polimod; PGT/1A; (R)-3-((S)-(5-Oxo-2-pyrrolidinyl)carbonyl)-thiazolidin-4-carbonsaeure [German]; (R)-3-((S)-5-Oxoprolyl)-4-thiazolidinecarboxylic acid; (R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid; (R-(R*,S*))-3-((5-Oxo-2-pyrrolidinyl)carbonyl)-4-thiazolidinecarboxylic acid; 121808-62-6; 785363R681; BRN 6636310; C9H12N2O4S; CCRIS 7271; NCGC00160516-01; UNII-785363R681
Indication Pulmonary tuberculosis [ICD11: 1B10] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 244.27 Topological Polar Surface Area 112
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
65944
ChEBI ID
CHEBI:94618
CAS Number
121808-62-6
Formula
C9H12N2O4S
Canonical SMILES
C1CC(=O)NC1C(=O)N2CSCC2C(=O)O
InChI
1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
InChIKey
UUTKICFRNVKFRG-WDSKDSINSA-N
The Predicted Metabolic Roadmap of This Drug
The Full List of Predicted Drug Metabolites (PDM) of This Drug
PDM Name PDM ID PubChem ID Reaction PDM Level Biosystem
Pidotimod M1 PDM007395
64890103
Hydrolysis - Hydrolysis of cyclic secondary carboxamide 1 Human
Pidotimod M2 PDM007396 N. A. Conjugation - Glycine conjugation 1 Human
Pidotimod M3 PDM007397 N. A. Conjugation - alpha-N-Acetylation of peptide 1 Human
Pidotimod M4 PDM007398 N. A. Conjugation - O-Glucuronidation of aliphatic acid 1 Human
Pidotimod M5 PDM007399 N. A. Conjugation - Carnitine conjugation 1 Human
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1254 Bacteroides thetaiotaomicron Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1256 Bacteroides sartorii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1364 Bacteroides coprophilus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1376 Bacteroides ovatus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1379 Bacteroides stercoris Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1393 Blautia hansenii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1402 Clostridium botulinum Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1445 Parabacteroides distasonis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1446 Parabacteroides johnsonii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1449 Prevotella copri Not Available Not Available [2]
⏷ Show the Full List of 12  DME(s)
References
1 ClinicalTrials.gov (NCT04322669) Study of Pidotimod in Children With Recurrent Respiratory Tract Infections (RRI)
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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