Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2286)
Drug Name
QC-1571
Synonyms
Fenspirid; Fenspirida; Fenspiride; Fenspirida [INN-Spanish]; Fenspiride (INN); Fenspiride [INN]; Fenspiridum; Fenspiridum [INN-Latin]; Respiride; S983QC7HKM; Viarespan; fenspiride; 1-Oxa-3,8-diazaspiro(4,5)decan-2-one, 8-(2-phenylethyl)-; 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-phenylethyl)-; 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one; 8-Phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; 8-Phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one; BRN 0533332; C15H20N2O2; EINECS 225-751-3; UNII-S983QC7HKM
Indication Chronic laryngitis [ICD11: CA0G] Preclinical [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.329 Topological Polar Surface Area 41.6
Heavy Atom Count 19 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Cross-matching ID
PubChem CID
3344
ChEBI ID
CHEBI:94558
CAS Number
5053-08-7
Formula
C15H20N2O2
Canonical SMILES
C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
InChI
1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)
InChIKey
FVNFBBAOMBJTST-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
QC-1571 Metabolite B DM006496 N. A. Unclear 1 [3]
QC-1571 Metabolite H DM006497 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006989 QC-1571 QC-1571 Metabolite B Unclear Unclear [3]
MR006990 QC-1571 QC-1571 Metabolite H Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1254 Bacteroides thetaiotaomicron Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1256 Bacteroides sartorii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1364 Bacteroides coprophilus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1376 Bacteroides ovatus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1379 Bacteroides stercoris Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1446 Parabacteroides johnsonii Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1449 Prevotella copri Not Available Not Available [2]
⏷ Show the Full List of 8  DME(s)
References
1 The use of fenspiride for the combined treatment of exacerbation of chronic laryngitis. Vestn Otorinolaringol. 2017;82(6):66-69.
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Detection of fenspiride and identification of in vivo metabolites in horse body fluids by capillary gas chromatography-mass spectrometry: administration, biotransformation and urinary excretion after a single oral dose

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