Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN121)
DME Name Carboxylesterase (CES), Homo sapiens
Gene Name CES
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Latanoprost
 Drug Info Approved Glaucoma ICD11: 9C61 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
E-6005
 Drug Info Phase 2 Atopic dermatitis ICD11: EA80 [2]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
GTPL-1666
 Drug Info Phase 1 Cerebral vasospasm ICD11: BA85 [3]
RTR-001007
 Drug Info Phase 1 Diabetes mellitus ICD11: 5A10 [4]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008716 Cilazapril Cilazaprilat Hydrolysis - Hydrolysis Cilazapril [5]
MR014197 CZ48 Camptothecin Hydrolysis - Hydrolysis CZ48 [6]
MR007738 Dipivefrin Epinephrine Hydrolysis - Hydrolysis dipivefrin [7]
MR007445 E-6005 E-6005 M11 Hydrolysis - Hydrolyzation E-6005 [2]
MR008751 Flumazenil Ro 15-3690 Hydrolysis - Hydrolysis Flumazenil [8]
MR003913 GTPL-1666 SalB Unclear - Unclear GTPL-1666 [3]
MR010493 JNJ-54861911 DIAT Unclear - Unclear JNJ-54861911 [9]
MR006923 beta-hydroxy acid of lovastatin 3''-Hydroxylovastatin Unclear - Unclear Lovastatin [10]
MR009700 Ramipril Ramiprilat Hydrolysis - De-esterification Ramipril [11]
MR003975 RTR-001007 Caffeic acid Hydrolysis - Hydrolysis RTR-001007 [4]
MR006840 Spirapril Spiraprilat Hydrolysis - Esterolysis Spirapril [12]
⏷ Show the Full List of 11 MR(s)
References
1 Latanoprost in the treatment of glaucoma
2 Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: results of a randomized, vehicle-controlled, multicenter clinical trial. J Dermatol. 2014 Jul;41(7):577-85.
3 In vitro stability and metabolism of salvinorin A in rat plasma
4 In vitro and in vivo stability of caffeic acid phenethyl ester, a bioactive compound of propolis
5 Angiotensin-converting enzyme (ACE)-inhibition in cirrhosis. Pharmacokinetics and dynamics of the ACE-inhibitor cilazapril (Ro 31-2848)
6 Sustained delivery of a camptothecin prodrug - CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity
7 Site of ocular hydrolysis of a prodrug, dipivefrin, and a comparison of its ocular metabolism with that of the parent compound, epinephrine
8 Plasma pharmacokinetics and metabolism of the benzodiazepine antagonist [11C] Ro 15-1788 (flumazenil) in baboon and human during positron emission tomography studies
9 Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat
10 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
11 The analysis of ramipril/ramiprilat concentration in human serum with liquid chromatography-tandem mass spectrometry - interpretation of high concentrations for the purposes of forensic toxicology
12 Spirapril: pharmacokinetic properties and drug interactions

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