Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM004544)
DM Name	O-Desmethylnaproxen acyl glucuronide

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 1A10 (UGT1A10)	DME0075	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 1A6 (UGT1A6)	DME0072	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 1A7 (UGT1A7)	DME0065	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	O-Desmethylnaproxen	Conjugation - Glucuronidation	Naproxen	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Naproxen		DR1130	Approved		Rheumatoid arthritis

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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