General Information of Drug Metabolite (DM) (ID: DM019627)
DM Name
LIK-066 M13,14
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Oxidation - Oxidation LIK-066 [1]
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - Oxidation LIK-066 [1]
Cytochrome P450 2C9 (CYP2C9) DME0019 Oxidation - Oxidation LIK-066 [1]
Cytochrome P450 2J2 (CYP2J2) DME0031 Oxidation - Oxidation LIK-066 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Oxidation LIK-066 [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - Oxidation LIK-066 [1]
Full List of Drug(s) That Produce This DM By Metabolism
LIK-066 DR3265 Phase 2 Heart failure
References
1 Pharmacokinetics, metabolism, and excretion of licogliflozin, a dual inhibitor of SGLT1/2, in rats, dogs, and humans

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