Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM019798)
DM Name	PT2385 M12
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DME0042	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 2B15 (UGT2B15)	DME0049	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 2B17 (UGT2B17)	DME0066	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]
UDP-glucuronosyltransferase 2B4 (UGT2B4)	DME0047	PT2385 M7	Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation	PT2385	[1]

Full List of Drug(s) That Produce This DM By Metabolism
PT2385		DR3296	Phase 2		Von hippel-lindau disease

References
1	Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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