General Information of Drug Metabolite (DM) (ID: DM019797)
DM Name
PT2385 M7
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - Oxidative Defluorination PT2385 [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - Oxidative Defluorination PT2385 [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047 Multi-steps Reaction - Oxidative Defluorination; Glucuronide conjugation PT2385 [1]
Full List of Drug(s) That Produce This DM By Metabolism
PT2385 DR3296 Phase 2 Von hippel-lindau disease
References
1 Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2 Inhibitor PT2385 In Vivo and In Vitro

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