Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2300)
Drug Name
Pericyazine
Synonyms
Periciazina; Periciazina [INN-Spanish]; Periciazine; Periciazinum; Periciazinum [INN-Latin]; Propericiazine (JAN); Propericiazine(jan); Aolept; Nemactil; Neulactil; Neulactil (TN); Neuleptil; Neuleptil (TN); PERICYAZINE; RP 8908; SKF 20,716; WH 7508; 10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile; 10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile; 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile; 2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine; 2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine; 6909 RP; Bayer 1409; Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine; Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine [French]; IC 6002; Piperocyanomazine;Periciazine [INN]
Indication Anxiety disorder [ICD11: 6B00] Phase 4 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 365.5 Topological Polar Surface Area 75.8
Heavy Atom Count 26 Rotatable Bond Count 4
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
4747
PubChem SID
7703132 ; 7848548 ; 7980281 ; 8150082 ; 8152913 ; 10516133 ; 11336049 ; 11361288 ; 11364508 ; 11367070 ; 11369632 ; 11371656 ; 11373958 ; 11377794 ; 11462260 ; 11485343 ; 11489420 ; 11490564 ; 11492025 ; 11495428 ; 14803709 ; 26612557 ; 26680430 ; 26748871 ; 26748872 ; 29223833 ; 46505085 ; 47291188 ; 47810806 ; 48259291 ; 50006266 ; 50107474 ; 56464150 ; 57322425 ; 79997266 ; 85789600 ; 92124822 ; 99301962 ; 103555929 ; 103846500 ; 104307313 ; 117515052 ; 124636904 ; 126673224 ; 128541428 ; 131349353 ; 134224641 ; 134337709 ; 134982092 ; 136913034
ChEBI ID
ChEBI:31981
CAS Number
2622-26-6
TTD Drug ID
D00AWT
Formula
C21H23N3OS
Canonical SMILES
C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI
1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
InChIKey
LUALIOATIOESLM-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
7-hydroxypericyazine DM002756 N. A. Unclear 1 [3]
Sulphoxide pericyazine DM002757 N. A. Unclear 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001993 Pericyazine 7-hydroxypericyazine Unclear Unclear [3]
MR001994 Pericyazine Sulphoxide pericyazine Unclear Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Unclear metabolic mechanism (DME-unclear) DME1251 Bacteroides fragilis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1254 Bacteroides thetaiotaomicron Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1357 Alistipes indistinctus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1365 Bacteroides dorei Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1384 Bacteroides vulgatus Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1445 Parabacteroides distasonis Not Available Not Available [2]
Unclear metabolic mechanism (DME-unclear) DME1446 Parabacteroides johnsonii Not Available Not Available [2]
⏷ Show the Full List of 7  DME(s)
References
1 National Center for Advancing Translational Science-Inxight: drug (3405M6FD73)
2 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
3 Excretion and metabolism of milnacipran in humans after oral administration of milnacipran hydrochloride Drug Metab Dispos. 2012 Sep;40(9):1723-35. doi: 10.1124/dmd.112.045120.

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