Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR1006)
Drug Name
Meclizine
Synonyms
Meclizine [INN:BAN]; Meclizine hydrochloride; Meclozina [INN-Spanish]; Meclozine; Meclozinum [INN-Latin]; Monamine; Navicalm; Ancolan; Ancolon; Antivert; Bonadettes; Bonine; Calmonal; Chiclida; Diadril; Dramamine II; Histamethine; Histamethizine; Histametizine; Histametizyne; Itinerol; Neo-istafene; Neo-suprimal; Neo-suprimel; Parachloramine; Peremesin; Postafene; Ravelon; Sabari; Sea-Legs; Siguran; Subari; Suprimal; Travelon; UCB 170; UCB 5062; Vomisseis; Vomissels; meclizine; (+-)-Meclizine; 569-65-3; Marex
Indication Functional nausea/vomiting [ICD11: DD90] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 390.9 Topological Polar Surface Area 6.5
Heavy Atom Count 28 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Cross-matching ID
PubChem CID
4034
PubChem SID
9327 ; 442158 ; 4782133 ; 7979876 ; 8152525 ; 10527723 ; 11335582 ; 11360821 ; 11363785 ; 11366347 ; 11368909 ; 11371549 ; 11373612 ; 11377071 ; 11461793 ; 11466485 ; 11467605 ; 11483836 ; 11486209 ; 11487926 ; 11490301 ; 11491852 ; 11494705 ; 14805236 ; 29223145 ; 46507782 ; 47440184 ; 47515252 ; 47810681 ; 47959664 ; 48035039 ; 48110390 ; 48334421 ; 48416201 ; 49698867 ; 50012193 ; 50807781 ; 57322105 ; 76715647 ; 85209822 ; 85788825 ; 96024853 ; 103604960 ; 104305237 ; 117409993 ; 124883625 ; 124883627 ; 125312386 ; 125823630 ; 126689207
ChEBI ID
CHEBI:6709
CAS Number
569-65-3
TTD Drug ID
D0T1XW
Formula
C25H27ClN2
Canonical SMILES
CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
InChI
1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
InChIKey
OCJYIGYOJCODJL-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Meclizine metabolite M1 DM001078 N. A. Oxidation - Hydroxylation 1 [2]
Meclizine metabolite M2 DM001079 N. A. Oxidation - Benzylic Oxidation 1 [2]
Norchlorcyclizine DM001077
9340
Oxidation - Hydroxylation 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001610 Meclizine Norchlorcyclizine Oxidation - Hydroxylation CYP2D6 [2]
MR001611 Meclizine Meclizine metabolite M1 Oxidation - Hydroxylation CYP2D6 [2]
MR001612 Meclizine Meclizine metabolite M2 Oxidation - Benzylic Oxidation CYP2D6 [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 2D6 (CYP2D6) DME0009 Homo sapiens
CP2D6_HUMAN
1.14.14.1
[2]
References
1 Meclizine was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012 Sep;52(9):1343-9.

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