Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001610)
Formula
SVG example
Hydroxylation
Reactant Meclizine Product Norchlorcyclizine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001611 Meclizine Meclizine metabolite M1 Oxidation - Hydroxylation Meclizine [1]
MR001612 Meclizine Meclizine metabolite M2 Oxidation - Benzylic Oxidation Meclizine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012571 Chlorcyclizine Norchlorcyclizine Unclear - Unclear Chlorcyclizine [2]
References
1 Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012 Sep;52(9):1343-9.
2 A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro

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