Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1376)
DME Name Unclear metabolic mechanism (DME-unclear), Bacteroides ovatus
Gene Name DME-unclear
Lineage    Species: Bacteroides ovatus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides ovatus
Subspecies: Bacteroides ovatus ATCC 8483
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        31 Drugs
Galantamine hydrobromide
 Drug Info Approved Alzheimer disease ICD11: 8A20 [1]
Naloxone
 Drug Info Approved Opiate dependence ICD11: 6C43 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Duloxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Carvedilol
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Digitoxin
 Drug Info Approved Congestive heart failure ICD11: BD10 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Diltiazem hydrochloride
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Oxaprozin
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Clonidine
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Procarbazine
 Drug Info Approved Anaplastic large cell lymphoma ICD11: 2A90 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Clopidogrel bisulfate
 Drug Info Approved Acute coronary syndrome ICD11: BA4Z [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Fluconazole
 Drug Info Approved Candidiasis ICD11: 1F23 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Benazepril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Telmisartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Valsartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Diflorasone diacetate
 Drug Info Approved Rosacea ICD11: ED90 [1]
Sotalol
 Drug Info Approved Atrial fibrillation ICD11: BC81 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          8 Drugs
Famprofazone
 Drug Info Phase 4 Anaesthesia ICD11: 8E22 [1]
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Idebenone
 Drug Info Phase 4 Mitochondrial myopathy ICD11: 8C73 [1]
L-phenylalanine
 Drug Info Phase 4 Phenylketonuria ICD11: 5C50 [2]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Pidotimod
 Drug Info Phase 4 Pulmonary tuberculosis ICD11: 1B10 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
OPC-12759
 Drug Info Phase 3 Peptic ulcer ICD11: DA61 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
W-108598
 Drug Info Phase 2 Myasthenia gravis ICD11: 8C60 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TRP-01
 Drug Info Phase 1 Depression ICD11: 6A71 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
QC-1571
 Drug Info Preclinical Chronic laryngitis ICD11: CA0G [1]
L-tyrosine
 Drug Info Investigative Phenylketonuria ICD11: 5C50 [2]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35.

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