Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1449)
DME Name Unclear metabolic mechanism (DME-unclear), Prevotella copri
Gene Name DME-unclear
Lineage    Species: Prevotella copri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella copri
Subspecies: Prevotella copri DSM 18205
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        37 Drugs
Naloxone
 Drug Info Approved Opiate dependence ICD11: 6C43 [1]
Linagliptin
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Terbinafine hydrochloride
 Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Deflazacort
 Drug Info Approved Muscular dystrophy ICD11: 8C70 [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Fluoxetine hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Riluzole
 Drug Info Approved Amyotrophic lateral sclerosis ICD11: 8B60 [1]
Aspirin
 Drug Info Approved Myocardial infarction ICD11: BA41 [2]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Famciclovir
 Drug Info Approved Genital herpes ICD11: 1A94 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Tolazamide
 Drug Info Approved Diabetes mellitus ICD11: 5A10 [1]
Vilazodone hydrochloride
 Drug Info Approved Depression ICD11: 6A71 [1]
Clemastine fumarate
 Drug Info Approved Pulmonary oedema ICD11: CB01 [1]
Fenofibrate
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Carisoprodol
 Drug Info Approved Depression ICD11: 6A71 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Nivolumab
 Drug Info Approved Lung cancer ICD11: 2C25 [3]
Quinapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Trandolapril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Benazepril
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Fluphenazine decanoate
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Valsartan
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Carboplatin
 Drug Info Approved Ovarian cancer ICD11: 2C73 [4]
Cetirizine
 Drug Info Approved Allergy ICD11: 4A80 [1]
Dicyclomine
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
Diflorasone diacetate
 Drug Info Approved Rosacea ICD11: ED90 [1]
Ramelteon
 Drug Info Approved Insomnia ICD11: 7A00 [1]
Sotalol
 Drug Info Approved Atrial fibrillation ICD11: BC81 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          6 Drugs
Famprofazone
 Drug Info Phase 4 Anaesthesia ICD11: 8E22 [1]
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Pidotimod
 Drug Info Phase 4 Pulmonary tuberculosis ICD11: 1B10 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Roxatidine
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
BRN-0889798
 Drug Info Phase 2 Keratoconjunctivitis sicca ICD11: 9A79 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
QC-1571
 Drug Info Preclinical Chronic laryngitis ICD11: CA0G [1]
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Gut microbiota-mediated drug-drug interaction between amoxicillin and aspirin. Sci Rep. 2019 Nov 7;9(1):16194.
3 The diversity of gut microbiome is associated with favorable responses to anti-programmed death 1 immunotherapy in Chinese patients with NSCLC. J Thorac Oncol. 2019 Aug;14(8):1378-1389.
4 revotella copri is associated with carboplatin-induced gut toxicity. Cell Death Dis. 2019 Sep 26;10(10):714.

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