Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000041)
Formula Reactant Acemetacin Product O-desmethyl-des-4-chlorobenzoyl
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000039 Acemetacin Deacyl indomethacin Other reaction - N-Dehydroxylation; Hydrolysis Acemetacin [1]
MR000042 Acemetacin Indomethacin Hydrolysis - Esterase Hydrolysis Acemetacin [1]
MR000040 Acemetacin O-demethylatedacemetacin Oxidation - O-Demethylation Acemetacin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000038 O-desmethyl-des-4-chlorobenzoyl Des-p-chlorobenzoyl-O-desmethylindometacinsulfate Unclear Acemetacin [2]
MR000037 O-desmethyl-des-4-chlorobenzoyl O-desmethyl-des-4-chlorobenzoyl glucuronide Conjugation - Glucuronidation Acemetacin [1]
References
1 DrugBank(Pharmacology-Metabolism)Acemetacin
2 [Comparative metabolic studies on [14C]-labelled acemetacin and indometacin in rats (author's transl)] Arzneimittelforschung. 1980;30(8A):1384-91.

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