Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007514)
Formula
SVG example
Reactant Inosine Product IMP
Reactant Info Product Info
Metabolic Enzyme Hypoxanthine phosphoribosyltransferase (HPRT1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007507 Inosine Hypoxanthine Unclear Inosine [1], [2]
MR007513 Inosine Unclear Unclear Inosine [1], [2]
MR000078 Inosine Hypoxanthine Other reaction - Phosphorylation Adenosine [3], [4]
MR000083 Inosine Adenosine phosphate metabolite Hx (hypoxanthine) Unclear Adenosine phosphate [5], [6], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000082 Adenosine phosphate Adenosine phosphate metabolite IMP Unclear Adenosine phosphate [5], [4]
MR011568 ZMP IMP Unclear - Unclear Acadesine [7]
MR004026 GMP IMP Unclear Xanthine [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000081 Adenosine phosphate metabolite IMP Inosine Unclear Adenosine phosphate [5], [4]
MR011569 IMP AMP Unclear - Unclear Acadesine [7]
MR004027 IMP SAMP Unclear Xanthine [8]
References
1 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
2 Inosine in Biology and Disease
3 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
4 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
5 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.
6 Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway. Radiat Res. 2022 Jun 1;197(6):583-593. doi: 10.1667/RADE-21-00223.1.
7 A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy
8 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism

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