Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000169)
Formula
CYP2C19 ...
SVG example
N-Dealkylation
Reactant Aminophenazone Product 4-(Dimethylamino)-5-methyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000168 Aminophenazone Aminophenazone metabolite I Unclear Aminophenazone [1]
MR000170 Aminophenazone N-Desmethylaminopyrine Oxidation - N-Dealkylation Aminophenazone [2]
References
1 U. S. FDA Label - Aminophenazone
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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